Frequency and quantity of intrathecal antibodies

http://www.neurology.org/cgi/content/abstract/61/1/125

Neurology 2003;61:125-128
K. Rostasy, MD, H. Reiber, PhD, D. Pohl, MD, P. Lange, BSc, A. Ohlenbusch, PhD, H. Eiffert, MD, M. Maass, MD and F. Hanefeld, MD
Department of Pediatric Neurology (Drs. Rostasy, Pohl, Ohlenbusch, and Hanefeld), Neurochemistry Laboratory (Drs. Reiber and Lange), and Department of Bacteriology (Dr. Eiffert), University of Göttingen; and Institute of Medical Microbiology and Hygiene (Dr. Maass), University of Lübeck, Germany.

The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS.

C pneumoniae genome was present in two children.

In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.