All About Multiple Sclerosis

More MS news articles for July 2003

Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12838528&dopt=Abstract

Ann Neurol. 2003 Jul;54(1):119-22
Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G.
Laboratoire Universitaire d'Immunologie (UPRES EA 1257, IFR 97) and Etablissement Francais du Sang Bretagne, Faculte de Medecine, Rennes.

Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component.

Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype.

In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility.

Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.