1 August 2002
Multiple Sclerosis, vol. 8, no. 4, pp. 295-298(4)
Schreiber K; Oturai AB; Ryder LP; Madsen HO; Jørgensen OS; Svejgaard A; Sorensen PS
 Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark  Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark  Laboratory of Neuropsychiatry, Department of Pharmacology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
As the understanding of the autoimmune inflammatory response in multiple sclerosis (MS) expands, polymorphic genes involved in this process become possible candidates that may determine the severity of disease.
Therefore, three candidate genes DRB1*1501, CCR5 and apolipoprotein E (APOE) were examined in a population-based patient sample (n=70) to assess an association between disease progression measured by clinical disability and MRI parameters.
The total lesion area (TLA) on T2-weighted images was measured with a semi-automated threshold technique.
Patients with the CCR5D32 allele showed a non-significant trend towards a smaller lesion burden (TLA/years duration), but were not associated to a milder EDSS/years duration.
Our data support previous assumptions of a modulation of severity in MS by the CCR5D32 genotype, which may convey less inflammation and tissue destruction.
Carriers of the DRB1*1501 and APOE-e4 alleles did not reveal more severe disease progression, neither by the EDSS/years of duration nor by the TLA/years duration.
This study was performed on a population-based sample in a genetically homogeneous Danish population but, due to the limited number of patients examined, weak associations between candidate genes and disease variables cannot be excluded.
© 2002 ingenta