More MS news articles for July 2002

Expansion of CD5 B Cells in Multiple Sclerosis Correlates with CD80 (B7-1) Expression

Scand J Immunol 2002 Jul;56(1):101-107
Sellebjerg F, Jensen J, Jensen C, Wiik A.

The pathogenetic role of autoantibodies in multiple sclerosis (MS) is uncertain.

CD5+ B cells commonly produce autoantibodies, but CD5 expression has also been implicated in B-cell tolerance.

We studied B-cell subsets, anti-myelin protein antibody-secreting cells in cerebrospinal fluid (CSF) and a panel of serum autoantibodies in patients with clinically isolated syndromes (CIS), suggestive of MS and patients with clinically definite MS (CDMS).

Patients with CDMS had a higher percentage of CD5- B cells in CSF than did control subjects (P = 0.02).

CIS patients with immunoglobulin G (IgG) oligoclonal bands in CSF or multiple lesions on magnetic resonance imaging (MRI) had a higher percentage of CD5- B cells in CSF than did the remaining CIS patients (P = 0.03).

The percentage of CD5- and CD80+ B cells correlated positively and the percentage of CD5+ B cells correlated negatively with the number of CSF cells secreting anti-myelin basic protein (anti-MBP) antibodies.

The prevalence of serum autoantibodies was comparable in the three patient groups.

We conclude that intrathecal expansion of CD5- B cells appears to be more characteristic in MS patients, and CD5+ B cells may be associated with a lower prevalence of anti-myelin antibody production.