Journal of Neurology
Abstract Volume 249 Issue 6 (2002) pp 723-729
Natalia Teleshova (1), Mikhail Pashenkov (1), Yu-Min Huang (1), Mats Söderström (2), Pia Kivisäkk (1), Vasilios Kostulas (1), Mats Haglund (3), Hans Link (1)
(1) Department of Neurology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden. Tel.: +46-8/5 85-8 22 78, Fax: +46-8/5 85-8 70 80
(2) Department of Ophthalmology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden
(3) Department of Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
A role for chemokines as mediators of Th1 cell recruitment to the central nervous system (CNS) is probable in MS.
Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls.
Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF.
Such elevation was not found in MS patients examined during ongoing treatment with IFN-<beta>.
Patients with optic neuritis (ON), a common first manifestation of MS, had elevated percentages of CXCR3 expressing T cells in blood compared with HC, and of CCR5 expressing T cells in CSF compared with OND patients.
High chemokine receptor expression may be one prerequisite for Th1 cells to migrate to the CNS.
Inhibition of chemokine receptor expression may
constitute a potentially important therapeutic effect of IFN-<beta>.
© Steinkopff Verlag 2002