By Veronica Rose
A DGReview of :
"Clinical and epidemiological study : multiple sclerosis and human herpesvirus 6"
Infection 2002 Vol30 No 3 pp145-149
The presence of antibodies against human-herpes virus-6 in patients with multiple sclerosis suggests that a viral reactivation may be an environmental factor, according to Spanish researchers.
Microbiologists and neurologists from university hospitals in Granada and Madrid obtained 211 samples of serum and cerebrospinal fluid (139 sera and 72 CSF) from patients with multiple sclerosis (MS) in order to investigate a potential link between MS and Human herpesvirus-6 (HHV-6).
Using polymerase chain reaction (PCR) and EIISA, the presence of HHV-6DNA was investigated together with antibodies against HHV- 6, cytomegalovirus (CMV) and the Epstein -Barr virus (EBV).
Samples were grouped into three. Group I consisted of paired samples of serum and CSF from 41 patients with MS; Group II, paired samples of sera and CSF with 31 neurological patients without MS (OND) and Group III included 67 serum samples from 27 different MS patients who were undergoing serologic follow-up.
The researchers detected no HHV-6 DNA in any sample. In-Group I elevated
levels of anti-HHV-6 IgG and IgA in the serum was detected. Anti-CMV IgG
was seen in one Cerebrospinal fluid dsample and anti-HHV-6 IgM in a serum
sample from group II. Group III sera revealed high concentrations of anti
HHV-6 IgG, IgA and IgM.
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