J Neuroimmunol 2001 Jun 1;116(2):238-41
Zayas MD, Lucas M, Solano F, Fernandez-Perez
MJ, Izquierdo G
Servicio de Biologia Molecular, Hospital
Universitario Virgen Macarena, Avda. Dr. Fedriani s/n, 41009, Sevilla,
Spain
We have analyzed a CA repeat polymorphism
localized 46-kb upstream of the Fas ligand gene in Spanish and American
populations that include 139 healthy controls and a cohort of 177 unrelated
relapsing and remitting multiple sclerosis (MS) patients.
The MS patients consisted of two
groups, one with a family history of MS and one without.
The frequency of the 13 CA repeats
(allele B) was lower (p=0.01) in MS patients than in controls, 0.45 and
0.55 respectively.
The odds ratio (BB vs. AB/AA) for
MS patients vs. healthy controls was 0.51 (95% CI 0.3-0.9; p=0.01).
The odds ratio (BB vs. AB/AA) for
MS patients extracted from multiply affected families vs. healthy controls
was 0.22 (95% CI 0.07-0.62; p=0.002).
The HLA DRB1*1501-DQB1*0602 haplotype
is associated with B allele with a relative frequency higher than A allele
(0.52 and 0.48 in patients vs. 0.68 and 0.32 in controls).
The results suggest that chromosomes
with B allele have a genetic background that reduces susceptibility to
MS, particularly in the familial forms.
PMID: 11438180, UI: 21331907