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More MS news articles for January 2004

Distortion of the self-reactive IgG antibody repertoire in multiple sclerosis as a new diagnostic tool

J Immunol. 2004 Jan 1; 172(1): 669-78
Lefranc D, Almeras L, Dubucquoi S, de Seze J, Vermersch P, Prin L.
Laboratoire d'Immunologie Equipe d'Accueil 2686, Faculte de Medecine, Pole Recherche, 1 Place de Verdun, 59045 Lille Cedex, France

To date, none of the myelin-associated Ag targets definitively discriminates between the immune response observed in multiple sclerosis (MS) patients and healthy subjects.

However, it has been shown recently that analysis of global immune Ab profiles such as natural autoantibody reactivities can help to distinguish between normal individuals and patients suffering from various immune diseases.

The aim of our study was to compare the global IgG immune response against brain self-Ags in sera from 82 MS patients and 27 healthy subjects.

The analysis of the immune profiles was performed by Western blotting, and data were subjected to linear discriminant analysis.

Particular patterns of IgG reactivity were found in healthy subjects, Sjogren patients, and MS patients.

Moreover, this approach separated the three clinical forms of MS with a high concordance rate with the clinical data (kappa value, 77.8%).

Our study suggests, for the first time, that serum IgG Ab repertoires are able to distinguish MS patients.

In addition, our data suggest that patterns of IgG reactivity could model the pathological processes underlying the various forms of MS.

Further characterization of such discriminant Ags could provide useful information regarding their potent role in pathogenesis or regulatory processes in MS.