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More MS news articles for January 2004

The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure

J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):266-9
McGuigan C, Hutchinson M.
Department of Neurology, University College Dublin and St Vincent's University Hospital, Dublin, Ireland.


The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and in a hospital setting.


During an epidemiological study, 172 people with multiple sclerosis (MS) were examined and completed the MSIS-29, the London Handicap Scale, and Beck's Depression Inventory; disability was assessed by the Kurtzke Expanded Disability Status Score (EDSS) and the Multiple Sclerosis Functional Composite.

At the hospital neurology clinic, 102 MS patients completed the MSIS-29 and EDSS assessments were performed; 41 of these patients had repeat evaluations six months later.

The psychometric properties of the MSIS-29 were examined.


In the 172 community and the 102 hospital patients the psychometric properties of the MSIS-29 were satisfactory, with high convergent and low divergent validity.

It was significantly responsive to change in the contexts of self-reported change (p<0.034) and EDSS worsening (p<0.001).

The MSIS-29 physical score did not change over time when the EDSS was stable, and increased significantly in proportion to EDSS deterioration (p = 0.014).


The psychometric properties of the MSIS-29 are acceptable; it is a valuable outcome measure in intervention studies of patients with MS.