All About Multiple Sclerosis

More MS news articles for January 2004

A vulnerability locus to multiple sclerosis maps to 7p15 in a region syntenic to an EAE locus in the rat

Genes Immun. 2004 Jan;5(1):72-5
Coppin H, Ribouchon MT, Fontaine B, Edan G, Clanet M, Roth MP.
Unite de Physiopathologie Cellulaire et Moleculaire, Toulouse, France.

Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system.

Evidence from family studies indicates a strong genetic component.

Despite many studies of candidate genes, only an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been generally detected, and HLA linkage established by transmission disequilibrium testing.

A genome-wide scan revealed suggestive linkage of MS with markers on chromosome 7p15 in HLA-DR15-nonsharing British families, in a region syntenic to a locus predisposing to experimental autoimmune encephalomyelitis in the rat.

We therefore tested the 7p15 region as a candidate region for genetic susceptibility to MS in 104 French families with at least two affected siblings.

We found evidence suggestive of a predisposing locus in families in which only one affected sibling or none of them carry the HLA-DR15 allele.

Comparison of the results of the British and French groups suggests that the region of interest can be narrowed to a 2.45-cM interval.