J Neurol Neurosurg Psychiatry. 2004 Jan; 75(1): 152-154
Furrows SJ, Hartley JC, Bell J, Silver N, Losseff N, Stevenson S, Chapman M, Thompson EJ, Ridgway GL, Giovannoni G.
Microbiology Department, University College London Hospitals, London WC1E 6DB, UK. Microbiology, Hospital for Sick Children, Great Ormond St, London WC1N 3JH. Department of Infection Control National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG. Institute of Neurology, Queen Square, London WC1N 3BG.
Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis.
Previous studies show conflicting results.
To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae.
19 patients with multiple sclerosis and 29 with other neurological diseases were studied.
Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum.
C pneumoniae was grown from the CSF of one patient with multiple sclerosis.
PCR was negative in all cases.
Anti-chlamydial antibodies were detected in the same proportion in each group.
This study does not support the theory of an association between C pneumoniae and multiple sclerosis.