January 16, 2004
Boston Cure Project
In a recent MS genetics study, a set (haplotype) of variants in the interleukin-4 receptor (IL-4R) gene was tied to an increased risk of MS. Three previous studies of this gene had not produced much evidence of association with MS. However, in this new study the subjects were grouped into those who carry the MS-associated HLA-DR2 haplotype and those who don't. The IL-4R haplotype appeared to primarily be a risk factor for the non HLA-DR2 group. Hopefully future studies of this gene will also include the HLA stratification step so that these results can be checked.
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