Eur Radiol 2002 Dec;12 Suppl 4:S28-31
Tsui EY, Yip SF, Ng SH, Cheung YK.
Department of Radiology, Tuen Mun Hospital, Tuen Mun. NT, Hong Kong Special Administrative Region, The People's Republic of China
Multiple sclerosis (MS) patients occasionally present with homeostatic disturbances suggestive of hypothalamic dysfunction; however, the hypothalamus often appears normal on imaging, apart from confirmation in a few necropsy studies.
In this article we describe a Chinese woman with atypical clinical presentation.
She presented with relapsing symptoms and signs consistent with hypothalamic dysfunction including hyperprolactinema, syndrome of inappropriate secretion of anti-diuretic hormone (SIADH), hypersomnolence and temperature dysregulation.
Serial MRI depicted the atypical reversible changes in the hypothalamus, correlating with the observed homeostatic abnormalities.