Semin Immunol 2003 Feb;15(1):23-32
Mahad DJ, Ransohoff RM.
Department of Neurosciences, Mail Code NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA
Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human central nervous system (CNS).
In MS, CNS inflammation is associated with demyelination and axonal degeneration, which leads to clinical presentation.
Expression and cellular localization of CCL2/MCP-1 and CCR2 in MS have been described in the three compartments: brain, cerebrospinal fluid (CSF) and blood.
Evidence from descriptive, transgenic, knockout and neutralizing studies of experimental autoimmune encephalomyelitis (EAE) points towards a nonredundant role of CCL2 and CCR2 in the recruitment of inflammatory infiltrate into the CNS.
Hence, CCL2 and CCR2 may be targets for specific and effective treatment in MS.