More MS news articles for Jan 2002

Visuoperceptual impairment in MS patients: nature and possible neural origins|1454376537210543070/-1052814329/6/7051/7051/7052/7052/7051/-1

Multiple Sclerosis, December 2001, vol. 7, no. 6, pp. 389-401(13)
Vleugels L. [2] *; Lafosse C. [2]; van Nunen A. [1]; Charlier M. [1]; Ketelaer P. [1]; Vandenbussche E. [2]
[1] Department of Rehabilitation, National Multiple Sclerosis Centre, B-1820 Melsbroek, Belgium [2] Laboratory for Research in Neuropsychology, Department of Neuro- and Psychophysiology, University Campus Gasthuisberg, University of Leuven, B-3000 Belgium [*] Correspondence: L Vleugels, Nationaal M.S. Centrum, Vanheylenstraat, 16, B-1820 Melsbroek, Belgium

Failures on visuoperceptual neuropsychological tasks (on neuropsychological tests of visuo-spatial perception or on tests concerning semantic properties of visual objects), may indicate focal deficits of visuoperceptual function, or could be the result of (an)other (peripheral) visual deficit(s), or be the effect of a more general cognitive decline.

In multiple sclerosis (MS) patients exhibiting sufficient visual acuity and not showing severe cognitive deterioration, impairment on a comprehensive set of 31 visuoperceptual neuropsychological tasks was compared with spatial resolution deficits (SRD), temporal resolution deficits (TRD) for visual stimuli, abnormal pattern shift visual evoked potential (PSVEP) responses, and failing scores on neuropsychological tasks other than visuoperceptual tasks.

Impairment on the visuoperceptual neuropsychological tasks was highly independent from the other abnormal visual and cognitive neurological impairments examined, suggesting that it mostly represented focal deficits.

Only TRD in both eyes related to this impairment and this relationship was rather weak. Thus in some MS patients a slowed visual information processing may be one of the combined deficits underlying visuoperceptual neuropsychological task impairment.

Given that SRD and TRD were not related to another stage of MS and reflect disturbances of a P (parvocellular channel and ventral stream projections) and M (magnocellular channel and dorsal stream projections) visual-system function respectively, demyelination of a certain M pathway may become a co-determinant of visuoperceptual neuropsychological task impairment more rapidly than damage to a certain P pathway.

© 2002 ingenta