More MS news articles for Jan 2002

Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls|1454376537210543070/-1052814329/6/7051/7051/7052/7052/7051/-1

Multiple Sclerosis, December 2001, vol. 7, no. 6, pp. 371-374(4)
Sotgiu S. [1] *; Piana A. [2]; Pugliatti M. [1]; Sotgiu A. [1]; Deiana G.A. [1]; Sgaramella E. [3]; Muresu E. [2]; Rosati G. [1]
[1] Istituto di Clinica Neurologica, Università di Sassari, Sassari, Italy [2] Istituto di Igiene e Medicina Preventiva, Università di Sassari, Sassari, Italy [3] Istituto di Neurochirurgia, Università di Sassari, Sassari, Italy [*] Correspondence: S Sotgiu, Instituto di Clinica Neurologica, Università di Sassari, Viale San Pietro, 10, I-07100-Sassari, Italy

Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon.

We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection.

Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies.

However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%).

Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.

© 2002 ingenta