Neurosci Lett 2002 Jan 4;317(1):33-36
Weber F, Rudel R, Aulkemeyer P, Brinkmeier H.
German Air Force Institute of Aviation Medicine, Department of Neurology, P.O. Box 1264 KFL, 82242, Furstenfeldbruck, Germany
Reversible block of sodium channels by endogenous substances was claimed to account for the fast relapses and remissions seen in demyelinating autoimmune disorders.
The pentapeptide QYNAD, isolated from the cerebrospinal fluid from patients with multiple sclerosis (MS), blocked Na(+) channels in various types of cultured cells.
We show that 100 &mgr;M QYNAD bath-applied to isolated rat sciatic nerve causes the amplitude and area of the compound nerve action potential to decrease by 30-40%, while the latency increases.
Wash-out reverses the changes in part.
This suggests that QYNAD may indeed
contribute to the fast symptom changes in MS and related diseases.
PMID: 11750990 [PubMed - as supplied
PMID: 11750990 [PubMed - as supplied by publisher]