J Neuroimmunol 2002 Jan;122(1-2):140-145
Laaksonen M, Pastinen T, Sjoroos M, Kuokkanen S, Ruutiainen J, Sumelahti ML, Reijonen H, Salonen R, Wikstrom J, Panelius M, Partanen J, Tienari PJ, Ilonen J.
Turku Immunology Centre and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520, Turku, Finland
We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients.
The most important predisposing haplotype was DRB1*15-DQB1*0602 (P<10(-6)) as expected and a weak predisposing effect of DRB1*04-DQB1*0302 was revealed after the elimination of DRB1*15-DQB1*0602. HLA-DRB1*01-DQB1*0501 and DRB1*13-DQB1*0603 were negatively associated with MS in transmission disequilibrium test, but only the DRB1*13-DQB1*0603 association remained significant (P=0.008) after the elimination of DRB1*15-DQB1*0602 haplotypes.
Based on this study HLA class II
haplotypes exhibit both predisposing and protective effects in MS.
PMID: 11777553 [PubMed - as supplied
PMID: 11777553 [PubMed - as supplied by publisher]