Rev Neurol 2001 Nov 1;33(9):809-811
Robinson Agramonte M, Reiber H,
Dorta Contreras AJ, Hernandez Diaz E.
Departamento de Neuroinmunologia;
Centro Internacional de Restauracion Neurologica (CIREN), La Habana, 11300,
Cuba.
INTRODUCTION.
The intrathecal response of IgG,
is the most frequent neuropathological sign in multiple sclerosis (MS)
patients beside the detection of oligoclonal IgG bands in cerebrospinal
fluid. At the same time the observation of an intrathecal antibody synthesis
(antibody index>?1.4) against neurotropic viruses like measles, rubella,
varicella zoster or herpes simple shows a higher frequency in MS than any
other chronic disease (MRZH reaction). We report the intrathecal, polyspecific
and oligoclonal immune response in patients with definitive MS.
PATIENTS AND METHODS.
CSF and serum were tested for Albumin,
IgG, IgM and IgA by standard immunochemical nephelometry assay while virus
specific antibodies in CSF and serum samples were evaluated by ELISA and
calculated as antibody index.
RESULTS.
Oligoclonal IgG by, isoelectric focusing
was detectable in all patients. A differential pattern of combined antibody
index against neurotropic virus was observed. The largest frequency of
a single species in the oligoclonal immune response was for measles antibodies,
while the antibody response was found as a combination with increased rubella
antibody index and VZ antibody index, respectively.
CONCLUSION.
Our results although preliminary
for our country, enrich the criteria about that MRZH reaction provide a
major neuroimmunological support to MS diagnosis.