More MS news articles for Jan 2002

Growth Factor Control of CNS Myelination

Developmental Neuroscience 23:4-5:2001, 327-337.
Song-Kyu Park, David Solomon, Timothy Vartanian
Department of Neurology, Beth Israel Deaconess Medical Center, Program in Neuroscience, Harvard Medical School, Boston, Mass., USA


The molecular signals required for initiating myelination and maintenance of the myelin internode are not known.

Several growth factor families have been implicated in promoting oligodendrocyte survival or differentiation and may have consequences on formation of myelin.

We developed a reliable assay for detecting ensheathment of neurites by oligodendrocytes in spinal cord explants.

This system was used to assay the effect of selected growth factors on myelin internode formation.

We examined the influence on myelination of the polypeptide growth factors neuregulin (NRG), platelet-derived growth factor (PDGF), leukemia inhibitory factor (LIF), and the thyroid hormone T3.

We found that NRG, PDGF, and T3 treatments enhanced myelination while LIF treatment inhibited it.

We furthermore found that the most potent combination of factors to enhance myelination was NRG and T3.

Our results demonstrate that the role of growth factors on CNS myelination can be reliably studied in a controlled in vitro environment and that the impact of individual or combinations of growth factors on myelination cannot be predicted by their known effects on oligodendrocyte survival, proliferation, or differentiation.

Copyright © 2001 S. Karger AG, Basel