Chin Med J (Engl) 2000 Apr;113(4):372-5
Zhu X, Zhang Y, Wang Q, Wang F.
Shanghai Institute of Immunology,
Shanghai Second Medical University, Shanghai 200025, China.
OBJECTIVE:
To investigate the distribution of
antigen-processing genes transporter associated with antigen processing
(TAP), low molecular weight proteasome (LMP2) and HLA-DM in the Shanghai
population and to explore the possible role of these genes in the genetic
susceptibility to autoimmune diseases IgA nephropathy(IgAN) and multiple
sclerosis(MS).
METHODS:
Eighty normal Shanghai Chinese, 60
patients with IgAN and 21 patients with MS were randomly selected and genotyped
for antigen-processing genes (TAP1, TAP2, LMP2, HLA-DMA and -DMB) using
polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) and
polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Two-locus linkage disequilibrium analysis was performed.
RESULTS:
Four TAP1, 6 TAP2, 2 LMP2, 3 DMA
and 4 DMB alleles were observed. Statistically significant associations
were found between TAP1B-TAP2A, TAP1B-LMP2H and TAP2D-HLA-DMA* 0101 (Pc
< 0.01). There was no association between antigen-processing genes and
either IgAN or MS.
CONCLUSION:
The polymorphisms of antigen-processing
genes in this Shanghai population are similar to those observed in the
other ethnic populations. No association was found between IgAN or MS and
any antigen-processing genes tested in Shanghai population.
PMID: 11775239 [PubMed - in process]