J Neuroimmunol. 2004 Mar;148(1-2):172-7
Floris S, Van Der Goes A, Killestein J, Knol DL, Barkhof F, Polman CH, Dijkstra CD, De Vries HE, Meilof JF.
Department of Molecular Cell Biology, VU Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
In active multiple sclerosis (MS) lesions macrophages expressing myeloid related protein (MRP) 8/14 are present.
The aim of this study was to determine whether serum levels of MRP8/14 complexes are related to disease activity in MS.
In a longitudinal study of 16 relapsing remitting (RR) MS patients that underwent monthly gadolinium diethylentriaminepenta acid (Gd-DTPA) magnetic resonance imaging (MRI), the relation between serum MRP8/14 levels and disease activity was investigated.
Patients were participating in a monoclonal antibody study targeting a specific T cell population (Vbeta5.2/5.3(+) T-cells).
In time, within patients large variations in serum MRP8/14 levels were observed.
Serum MRP8/14 levels were not related to changes in clinical disease activity or increase in Gd-DTPA lesion enhancement.
Neither did comparison of active (>1 relapse in follow-up period) with inactive (0-1 relapse) MS patients reveal any differences in MRP8/14 levels.
Therefore, we conclude that although MRP8/14 expression is a good histopathological marker for monocyte activation, serum levels of these proteins do not correlate with disease activity in RR MS.