All About Multiple Sclerosis

More MS news articles for February 2004

B cells in multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14766408&dopt=Abstract

Front Biosci. 2004 Jan 1;9:786-96
Burgoon MP, Gilden DH, Owens GP.
Departments of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262.

The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands.

Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown.

Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.