A DGReview of :"Original communication: The normal appearing grey matter in primary progressive multiple sclerosis A magnetisation transfer imaging study"
Feb 6th, 2003
By James Adams
Journal of Neurology
Magnetization transfer ratio imaging reveals significant abnormalities in normal appearing grey matter in patients with primary progressive multiple sclerosis.
The mechanism of disability is poorly understood in primary progressive multiple sclerosis (PPMS), which is characterized by a slow progression in disability without relapses and occurs in 10 to 15% of patients of multiple sclerosis, investigators explain.
The investigators, from Medicsight plc, the University College London and the London School of Hygiene and Tropical Medicine in England, studied 30 patients with PPMS and 30 age-matched controls.
Spin echo based magnetization transfer ratio imaging was used to examine lesions and normal appearing grey and white matter. Six parameters of the magnetization transfer ratio were measured using normalized intensity value histograms. Mean lesion magnetization transfer ratio and T2 lesion volume were also determined.
Kurtzke's expanded disability status scale was used to assess patient disability.
Results showed that patients had lower magnetization transfer ratios for both normal appearing grey and white matter compared with controls.
Multiple regression analysis revealed a significant relationship between disability scores and mean magnetization transfer ratio of normal appearing grey matter.
The investigators conclude that further research is warranted to determine the pathological basis and functional significance of grey matter abnormalities in primary progressive multiple sclerosis.
J Neurol 2003;250:1:67-74. "Original
communication: The normal appearing grey matter in primary progressive
multiple sclerosis A magnetisation transfer imaging study"
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