All About Multiple Sclerosis

More MS news articles for February 2003

Multiple sclerosis, interferon beta and clinical thyroid dysfunction

Acta Neurol Scand 2003 Feb;107(2):154-157
Kreisler A, De Seze J, Stojkovic T, Delisse B, Combelles M, Verier A, Hautecoeur P, Vermersch P; For the Groupe septentrional d'etude et de recherche sur la Sclerose en Plaques (G-SEP).
Department of Neurology, Lille University Hospital, Lille, France; Department of Neurology, Regional Hospital, Lens, France; Marcq-en-Baroeul, France; Department of Neurology, Regional Hospital, Valenciennes, France; Department of Neurology, Saint Philibert Hospital, Lomme, France.

The objective of this study was to investigate frequency and presentation of clinical thyroid dysfunction in patients treated with interferon beta (IFN-beta).

We have collected the cases of clinical thyroid dysfunction in 700 consecutive patients receiving IFN-beta for multiple sclerosis (MS).

Five patients (four women, one man) treated with IFN-beta1b developed hyperthyroidism.

Three of them have secondary progressive MS, and two have relapsing-remitting MS.

It was necessary to stop IFN-beta in three cases; these patients still require carbimazole after several months.

In the two other cases, hyperthyroidism disappeared spontaneously.

Two patients (one man and one woman) treated with IFN-beta1a developed hypothyroidism.

One of them required l-thyroxine.

Lastly, an increased thyroid volume without modification of thyroid hormones plasma levels was discovered in a patient receiving IFN-beta1a.

Among patients treated with IFN-beta, clinical thyroid dysfunction is much rarer than laboratory thyroid dysfunction.

However, this side-effect is sometimes severe.