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More MS news articles for February 2003

IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis

Folia Neuropathol 2002;40(3):151-3
Losy J, Niezgoda A, Zaremba J.
Department of Clinical Neuroimmunology, University School of Medicine, Poznan, Poland.

Interleukin-15 is a novel cytokine produced by monocytes/macrophages and sharing several biological activities with IL-2.

IL-15 induces T cell proliferation, enhances natural killer (NK) cell cytotoxicity and also stimulates B cells to proliferate and secrete immunoglobulins.

The purpose of our study was to measure IL-15 levels in the serum and CSF of 21 patients with relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI, 12 without enhancing MRI lesions and to compare the results with the control group.

IL-15 levels were measured by ELISA.

We found a significant increase of IL-15 in the sera of patients with MS in comparison with the control group consisting of 8 patients with tension headache.

IL-15 serum levels were highest in patients with active, gadolinium enhancing lesions.

IL-15 CSF levels were low and there was no difference between studied groups.

The results may suggest the contribution of IL-15 in the immunopathogenesis of multiple sclerosis.