Intern Med 2003 Jan;42(1):102-4
Kozuka T, Kojima K, Kaneda K, Takenaka K, Manabe Y, Hirata Y, Okuma S, Toki H, Tanimoto M.
Department of Internal Medicine II, Okayama University Medical School, Okayama.
A 53-year-old Japanese man with multiple sclerosis developed autoimmune neutropenia.
The neutrophil count was consistently less than 0.2 x 10(9)/l, irrespective of the disease activity of multiple sclerosis or the administration of immunosuppressive agents or granulocyte colony-stimulating factor.
After high-dose gamma-globulin therapy was started, temporary increases in the neutrophil count were observed.
Despite a wide spectrum of clinical manifestations in multiple sclerosis, autoimmune neutropenia has never been reported previously.