All About Multiple Sclerosis

More MS news articles for February 2003

Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis

J Neuroimmunol 2003 Feb;135(1-2):117-25
Kennel De March A, De Bouwerie M, Kolopp-Sarda MN, Faure GC, Bene MC, Bernard CC.
Laboratoire d'Immunologie du CHU, Faculte de Medecine, BP 184, 54500 Vandoeuvre les, 54000, Nancy, France

Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS).

In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC).

Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry.

MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin.

These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response.