A DGReview of :"Short-Term Correlations between Clinical and MR Imaging Findings in Relapsing-Remitting Multiple Sclerosis."
By Robert Short
American Journal of Neuroradiology (AJNR)
Magnetic resonance imaging measures of inflammatory activity are modest, but significant, in relation to short-term clinical attacks in relapsing-remitting multiple sclerosis (RRMS).
This was the finding of Dr M Rovaris of the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy, and colleagues.
In a 9-month, double-blinded, placebo-controlled study, the researchers investigated short-term correlations between clinical and magnetic resonance measures of disease activity in 239 patients with RRMS. Patients were randomly assigned to 20 mg glatiramer acetate or placebo.
They found that there were significant univariate correlations between the number of relapses during the study period and the number of enhancing lesions at baseline and during follow-up in the study population as a whole.
The researchers said, "In relapsing-remitting multiple sclerosis, magnetic resonance imaging measures of inflammatory activity are modestly but significantly correlated with the occurrence of clinical attacks over the short term."
AJNR Am J Neuroradiol 2003;24:1:75-81. "Short-Term
Correlations between Clinical and MR Imaging Findings in Relapsing-Remitting
© 1995-2003 Doctor's Guide Publishing Limited