Feb 05, 2002
MS patients with the HLA DR15 phenotype are more likely to be female and prone to an earlier disease onset, a new study suggested.
Researchers tested for the HLA DR15 phenotype in 729 patients with MS. All of the individuals were clinically assessed and their clinical records were evaluated.
Study findings showed that the presence of DR15 was associated with younger age at diagnosis and being female.
However, there was no association with disease course (relapsing-remitting or secondary-progressive versus primary-progressive type), disease outcome, specific clinical features or diagnostic certainty.
Even though DR15 carriers are more likely to be female and prone to an earlier disease onset, the results indicate that there is no association with other specific clinical outcomes or laboratory indices examined here, the authors concluded. This suggests that DR15 exerts a susceptibility rather than disease-modifying effect in MS.
The study appears in the February issue of the Journal of Neurology, Neurosurgery and Psychiatry.
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