More MS news articles for Feb 2002

Structure-based Design and Evaluation of MHC Class II Binding Peptides

Biologicals 2001 Sep-Dec;29(3-4):289-92
de Haan EC, Wauben MH, Grosfeld-Stulemeyer MC, Moret EE.
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, 3508 TB, The Netherlands

Structural information regarding binding of peptides to the major histocompatibility complex (MHC) class II molecule is of great use for the design of compounds that intervene in the interaction between the MHC-peptide-T-cell receptor (TCR) complex.

These compounds can be applied in the treatment of T-cell-mediated auto-immune disease for specific modulation of the disease process.

In case no crystal structure of the MHC molecule is available, homology models of the MHC molecule can be of importance.

Here we describe the construction of a homology model of the MHC class II molecule and binding of the peptide, that are involved in experimental auto-immune encephalomyelitis, a rat model for human multiple sclerosis.

The validity of the model was investigated using experimental data of peptides binding to this MHC molecule.

Copyright 2001 The International Association for Biologicals.