1 February 2002, vol. 8, no. 1, pp. 59-63(5)
Casanova B; Coret F; Valero C; Landete L; Pascual A; Vilchez J J
 Neurology Services of the University Hospital La Fe, Valencia, Spain
 The Clinic University Hospital, Valencia, Spain
 The University Hospital, Dr. Peset, Valencia, Spain
To study if there are different patterns of clinical activity - measured by the annual exacerbation rate (AER) - among relapsing-remitting multiple sclerosis (RRMS), ''early'' secondary multiple sclerosis (SPMS) and ''late'' SPMS.
A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR).
A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found.
The SPMS has a high clinical inflammatory
activity before and during its transformation from a RRMS.
© 2002 ingenta