More MS news articles for Feb 2002

High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up study

Multiple Sclerosis,
1 February 2002, vol. 8, no. 1,   pp. 59-63(5)
Casanova B[1]; Coret F[2]; Valero C[1]; Landete L[3]; Pascual A[2]; Vilchez J J[1]
[1] Neurology Services of the University Hospital La Fe, Valencia, Spain
[2] The Clinic University Hospital, Valencia, Spain
[3] The University Hospital, Dr. Peset, Valencia, Spain


To study if there are different patterns of clinical activity - measured by the annual exacerbation rate (AER) - among relapsing-remitting multiple sclerosis (RRMS), ''early'' secondary multiple sclerosis (SPMS) and ''late'' SPMS.


A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR).


A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found.


The SPMS has a high clinical inflammatory activity before and during its transformation from a RRMS.

© 2002 ingenta