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More MS news articles for December 2003

The transition from relapsing-remitting MS to irreversible disability: clinical evaluation

Neurol Sci. 2003 Dec;24 Suppl 5:S268-70
Trojano M, Paolicelli D, Bellacosa A, Cataldo S.
Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I-70124, Bari, Italy.

The development of a progressive course is by far the most deleterious event in the case of a multiple sclerosis (MS) patient.

It occurs in about 90% of relapsing remitting patients by 20-25 years from onset.

The clinical transition to secondary progressive MS is phenotypically distinctive and both patients and physicians acknowledge that a fundamental shift in the degree of responsiveness to anti-inflammatory therapies has occurred.

This review discusses the clinical studies that provided important findings relating to our understanding on different mechanisms that may contribute to irreversible disability in MS.