Curr Opin Biotechnol. 2003 Dec;14(6):652-8
Brodmerkel CM, Vaddi K.
Incyte Corporation, Building 400, Rte 141 and Henry Clay Road, 19880, Wilmington, DE, USA
Inflammatory diseases affect a significant portion of the population worldwide and have been intensely studied for several decades.
The advent of transgenic technology has allowed researchers to study individual gene contributions to the pathogenesis of these diseases.
This has been done using standard inflammatory disease models in transgenic animals and by identifying novel models through the spontaneous generation of disease in the transgenic animal.
Recent advances have been made in the understanding of rheumatoid arthritis, pulmonary inflammation, multiple sclerosis and inflammatory bowel disease through the use of transgenic animals in models of human inflammatory disease.