All About Multiple Sclerosis

More MS news articles for December 2003

Allogeneic hematopoietic stem cell transplantation in a patient affected by large granular lymphocyte leukemia and multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14648027&dopt=Abstract

Ann Hematol. 2003 Nov 26
La Nasa G, Littera R, Cocco E, Battistini L, Marrosu MG, Contu L.
Centro Trapianti di Midollo Osseo, Centro Regionale Trapianti, Ospedale "R. Binaghi" ASL n degrees 8, Via Is Guadazzonis, 3, 09126, Cagliari, Italy.

We describe a 57-year-old man, affected by large granular lymphocyte (LGL) leukemia and concomitant primary progressive multiple sclerosis (MS), treated with allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling.

The patient was conditioned with fludarabine, busulphan, and cyclophosphamide.

Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and short-term methotrexate.

At 3 years follow-up, the patient is in complete remission of LGL with a marked improvement in neurological conditions.

This is the first case of allogeneic HSCT in a patient with LGL leukemia and concomitant primary progressive MS.

Allogeneic HSCT, performed in our patient to cure the lymphoproliferative disorder, improved the clinical course of MS.