Ann Hematol. 2003 Nov 26
La Nasa G, Littera R, Cocco E, Battistini L, Marrosu MG, Contu L.
Centro Trapianti di Midollo Osseo, Centro Regionale Trapianti, Ospedale
"R. Binaghi" ASL n degrees 8, Via Is Guadazzonis, 3, 09126, Cagliari, Italy.
We describe a 57-year-old man, affected by large granular lymphocyte (LGL) leukemia and concomitant primary progressive multiple sclerosis (MS), treated with allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling.
The patient was conditioned with fludarabine, busulphan, and cyclophosphamide.
Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and short-term methotrexate.
At 3 years follow-up, the patient is in complete remission of LGL with a marked improvement in neurological conditions.
This is the first case of allogeneic HSCT in a patient with LGL leukemia and concomitant primary progressive MS.
Allogeneic HSCT, performed in our patient to cure the lymphoproliferative disorder, improved the clinical course of MS.