Ann Neurol. 2003 Dec;54(6):828-31
Buljevac D, Verkooyen RP, Jacobs BC, Hop W, van der Zwaan LA, van Doorn PA, Hintzen RQ.
Department of Neurology, Erasmus MC, 3000 CA Rotterdam, The Netherlands.
In this prospective study of 73 relapsing remitting multiple sclerosis patients followed up for a mean of 1.7 years, the relation was tested between serologically defined Chlamydia pneumoniae (CP) infection periods and exacerbation rate.
Episodes of serologically defined CP infections were observed in a subgroup, and these episodes were associated with increased risk for exacerbation.
CP polymerase chain reaction was positive in most of the CP seropositive patients.
No correlation was found between the anti-CP antibody increase and titers of control antibodies.