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More MS news articles for December 2003

C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14644039&dopt=Abstract

J Neuroimmunol. 2003 Dec;145(1-2):135-8
Miyagishi R, Niino M, Fukazawa T, Yabe I, Kikuchi S, Tashiro K.
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Sapporo 060-8638, Hokkaido, Kita, Japan

C-C chemokine receptor 2 (CCR2) is a receptor for chemoattractant protein-1 (MCP-1) and associated with infiltrating lymphocytes in chronic active multiple sclerosis (MS) lesions.

To study the role of CCR2 gene in the development of MS, we investigated the CCR2-64I polymorphism in 122 MS patients and 112 healthy controls in a Japanese population.

We also analysed the influence of CCR2-64I polymorphism on the clinical course, age at disease onset, and severity.

The distribution of the CCR2-64I allele was significantly different between patients and controls (p=0.0187), and the 64I/64I homozygote was significantly less common in MS than in control.

Logistic analysis, adjusted for HLA-DRB1*1501-positivity, revealed negative association between the CCR2-64I and MS (p=0.0204).

There were no significant associations between CCR2 polymorphism and the clinical features of MS.

Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS.