All About Multiple Sclerosis

More MS news articles for December 2002

CTLA4 dimorphisms and the multiple sclerosis phenotype

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12458054&dopt=Abstract

J Neuroimmunol 2002 Oct;131(1-2):208-12
Masterman T, Ligers A, Zhang Z, Hellgren D, Salter H, Anvret M, Hillert J.
Department of Neurology, Karolinska Institutet at Huddinge University Hospital, S-141 86, Stockholm, Sweden

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), expressed on activated T cells, binds to B7 molecules on antigen-presenting cells.

Signaling via CTLA-4 results in downregulation of ongoing T-cell clonal expansion.

A single-nucleotide polymorphism (SNP) in exon 1 of CTLA4 is associated with susceptibility to several autoimmune diseases, including multiple sclerosis (MS).

In this two-stage study, we investigated whether haplotypes composed of exon 1-SNP alleles and alleles of a promoter-region SNP influence age at onset, disease severity and disease course in MS.

In stage 1, deviations in CTLA4 haplotype frequencies were observed in patients subgrouped by course; in stage 2, none of these original associations were confirmed.