O. O. Favorova, PhD, T. V. Andreewski, MSc, A. N. Boiko, MD, M. A. Sudomoina, PhD, A. D. Alekseenkov, MSc, O. G. Kulakova, PhD, A. V. Slanova, MSc and E. I. Gusev, MD
Department of Neurology and Neurosurgery (Drs. Boiko, Slanova, and Gusev) and Department of Molecular Biology and Medical Biotechnology (Drs. Favorova, Andreewski, Sudomoina, Alekseenkov, and Kulakova), Russian State Medical University, Moscow, Russia
The authors studied the possible association between the presence of a 32-base pair deletion allele in CC chemokine receptor 5 gene [3p21] (CCR5D32 allele) and the occurrence of MS.
The presence of CCR5D32 homozygotes among patients with MS indicates that the absence of CCR5 did not protect against MS.
Moreover, the CCR5D32 mutation was associated with MS in HLA-DR4–positive Russians (pcorr < 0.001, odds ratio [OR] = 25.0).
The (CCR5D32,DR4)-positive phenotype was negatively associated with early MS onset (at ages 18 years) (p = 0.0115, OR = 0.1).
© 2002 American Academy of Neurology