More MS news articles for Dec 2001

Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis

J Neuroimmunol 2001 Dec 3;121(1-2):120-5
Greve B, Magnusson CG, Melms A, Weissert R.
Department of Neurology, University of Tubingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany

IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type 1 and type 2 immunity.

IgE indices were significantly reduced in MS patients compared to controls.

In contrast, IgG1 was elevated in CSF of MS patients and elevated indices indicated intrathecal synthesis.

Because isotype switching to IgE and IgG4 is driven by type 2 immunity and occurrence of IgG1 has previously been found in type 1 immunity-dominated diseases, the results underscore a role of type 1 immunity in MS.

PMID: 11730948 [PubMed - in process]