More MS news articles for Dec 2001

IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis

J Neuroimmunol 2001 Dec 3;121(1-2):111-9
Traggiai E, Biagioli T, Rosati E, Ballerini C, Mazzanti B, Ben Nun A, Massacesi L, Vergelli M.
Department Neurological and Psychiatric Sciences, Viale Pieraccini 6, 50134, Florence, Italy

In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7.

In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease.

In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.

PMID: 11730947 [PubMed - in process]