More MS news articles for Dec 2001

Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease

J Neuroimmunol 2001 Dec 3;121(1-2):88-101
Clerici M, Saresella M, Trabattoni D, Speciale L, Fossati S, Ruzzante S, Cavaretta R, Filippi M, Caputo D, Ferrante P.
Cattedra di Immunologia, Universita degli Studi di Milano, DISP LITA Vialba, Via G.B. Grassi, 74, 20157, Milan, Italy

Peripheral blood mononuclear cells of multiple sclerosis (MS) patients were stimulated with myelin basic protein (MBP) together with anti-CD28 monoclonal antibody and staphylococcal enterotoxin B to optimize cytokine production by antigen-specific cells.

Type 1 (IL-2, IL-12, IFNgamma) and pro-inflammatory (TNFalpha, IL-1beta, IL-6) cytokines were augmented in CD4+, CD8+, and CD14+ cells of acute MS patients and of patients undergoing disease reactivation.

These cytokines were reduced in IFNbeta-treated and in stable MS patients; type 2 cytokines (IL-4, IL-10) were increased in these patients.

Similar immune profiles are seen in MS patients in whom remission is naturally or pharmacologically (IFNbeta) achieved.

Cytokine alterations are particularly evident in CD14+ cells, underlying their critical role in the modulation of the immune response.

PMID: 11730945 [PubMed - in process]