http://www.bmj.com/cgi/content/full/321/7273/1363
BMJ 2000;321:1363-1364 ( 2 December )
Time to start work on version 2
Despite the protestations of its boss, the National Institute for Clinical Excellence (NICE) is an instrument for rationing health care. 1 2 Unfortunately, it's not a very good one. A government with spine would learn from the failings of NICE and move on to version 2. Perhaps this is a job for after the next election, whoever wins.
NICE, which covers only England and Wales, began in 1999 with three main functions. 1 3-5 Firstly, it appraises new technologies, including drugs, and decides which should be encouraged in the NHS and which should be held back. Its other functions are to produce or approve guidelines and to encourage quality improvement. The biggest push for NICE came from political disapproval of "postcode prescribing:" patients on opposite sides of the same street may receive or be denied treatment because they fall under different health authorities, each with different policies on which treatments they will fund.
NICE began with a blaze of publicity by deciding that zanamivir, a new drug for treating flu, would not be made available in the NHS. 6 7 Its decision was based on the lack of evidence that the drug was effective in older people and others most at risk of serious harm from flu. It glossed over the fact that the same could be said for many, even most, treatments currently available on the NHS. Zanamivir's manufacturers, Glaxo Wellcome, were furious, and the chief executive threatened to take the company's research abroad.6 Last week, NICE reversed its decision on the drug, declaring that it would be available to at risk adults who present within 36 hours of developing symptoms when consultations for flu rise above 50 a week per 100 000 population.8 Just how easy it will be to implement such complex advice remains to be seen, but NICE boasted that the reversal of its guidance showed its commitment to evidence. A pooled analysis by the manufacturers showed that the drug would reduce symptoms in those at high risk from 6 to 5 days.
It's easier to
say yes than no
When NICE approves
treatmentssuch as taxanes for cancerthen there's little fuss, although
many cardiologists think that it oversold the use of intravenous glycoprotein
IIb/IIIa inhibitors in high risk patients who have had a heart attack,
perhaps because it was overinfluenced by the drug companies' secret evidence.
NICE's problems begin when it tries to deny treatments. It decided against
beta interferon for multiple sclerosis and promptly found itself facing
hostile publicity and an appeal from both the manufacturers and patients'
groups.9 Its final decision will not be available until the new year.
One failing of NICE
is that it's living a double lie. The first liewhich is as Orwellian as
its nameis to deny that it's about rationing health care, which might be
defined as "denying effective interventions." Denying ineffective interventions
is not rationing; rather it's what the Americans call a "no brainer." The
population is smart enough both to know that NICE is rationing health care
and that rationing of health care is inevitable. The second, and related,
lie is to give the impression that if the evidence supports a treatment
then it's made available and if it doesn't it isn't. In other words, the
whole messy problem of deciding which interventions to make available can
be decided with some data and a computer. It's a technical problem. This
lie corrupts the concept of evidence based medicine, which the BMJ has
long championed. The evidence supports decision making, but the evidence
can't make the decision. The values of the patient or the community must
be part of the decision. Effective interventions have adverse effects.
How can benefits be weighed against risks? How, for example, might an individual
woman or society balance the probable cardiovascular benefits of hormone
replacement therapy after the menopause against the increased risk of breast
cancer? This is not a technical problem. Similarly treatments that are
highly cost effective in those at high risk are also effective in those
at low riskbut at a very high cost. Deciding where cost effectiveness ends
is not a technical but an ethical judgement.
These failures with
honesty may lead to the ultimate failure of NICE, which could be the inability
to say no except in obvious cases. Beta interferon is effective in reducing
the progression of multiple sclerosis in some patients, and donezepil is
effective in slowing the progression of Alzheimer's disease in some patients.
A body that is not about rationing and is concerned primarily with evidence
might have to promote the wide use of both drugs within the NHS, whereas
a body that was honestly about rationing might legitimately say no to both
drugs. We shall see.
One off decisions
unbalance system
Another failure with
NICE is that it considers issues one at a time and is mostly concerned
with what's new and expensive. A better system, like the one in Oregon,
would look at all interventions. Otherwise a weak body that finds itself
saying yes to most new technologies will encourage the traditional unjust
rationing by delay (waiting lists), discrimination (against the elderly
and mentally ill), dilution (two nurses on a geriatric ward at night when
there should be four), and diversion (long term care moves to the social
sector). Patients with Alzheimer's disease might receive donepezil but
perhaps be worse off because they lose some of their nursing and social
care.
Transparency is vital
in an issue as difficult as rationing health care, and NICE has moved in
the right direction by deciding to make its preliminary determinations
public. Still, however, the process is far from transparent, and the suspicion
is that political clout is as important as evidence in the final decision.
Probably NICE had
to exist in order for us to begin to think about something better. A single
body cannot "solve" the problem of rationing, but Britain would benefit
from a body that admits it is about rationing, works openly, uses evidence,
looks right across health care, incorporates ethical thinking systematically
into its judgments, is more distant from politicians and the pharmaceutical
industry, and is directly accountable to the public. Let's call it CHORthe
Committee for Honest and Open Rationing.
Richard Smith, editor.
References
BMJ