Ann Univ Mariae Curie Sklodowska [Med]. 2002;57(2):376-80
Kwietniewska M, Cybulska R, Kwietniewski P, Sekita-Krzak J, Czerny K.
Department of Histology and Embryology, Lab of Experimental Cytology, Medical University of Lublin, Department of Histology and Embryology, Agricultural University of Lublin.
The experiment was carried out on rabbit females of New Zealand breed weighing about 3 kg.
Animals from the experimental group received Cladribine according to the schema of experimental treatment in the hairy cell leukemia and rabbits from the experimental group II--according to the schema of experimental treatment in multiple sclerosis.
Specimens of retina were collected for histological examinations in the light microscope.
It was revealed that administration of Cladribine in the dose corresponding to the therapeutic dose used in human for the treatment of the hairy cell leukemia and multiple sclerosis does not cause evident morphological changes in retinal ganglion cells on the level of light microscope.