Virus Res. 2003 Aug;94(2):97-101
Moles JP, Hadi JC, Guilhou JJ.
Laboratoire de Dermatologie Moleculaire, Institut Universitaire de Recherche Clinique, 641 avenue du Doyen G. Giraud, 34 093 cedex 5, Montpellier, France
Increasing evidence suggests that human endogenous retroviruses (HERV) could participate in the pathogenesis of autoimmune diseases such as multiple sclerosis and lupus erythematosus.
To assess a possible association of murine leukemia virus (MLV)-like group of HERVs with psoriasis we searched for antibodies against MLV proteins in the sera of patients.
We showed that anti-MLV antibodies (total) were detected in both psoriatic and control sera.
However, they were detected with a higher frequency in psoriasis when compared with controls (91 vs. 53%, respectively, P=0.001).
In addition, the IgG response was dramatically increased in psoriasis (86 vs. 8%, respectively, P<0.0001).
This immunoreactivity was observed against the products of both the gag and env genes, and the most antigenic proteins were the gp65-70.
Moreover, we observed that anti-p30 MLV antibodies reacted with an epidermal protein with a molecular weight of 50 kDa in protein extracts from both normal and psoriatic skin cultures.
These observations suggest that HERVs of the MLV-like group could contribute to the immunopathogenesis of psoriasis.