More MS news articles for August 2002

Two new HLA-B alleles, B*4422 and B*4704, identified in a study of families with autoimmunity

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12135438&dopt=Abstract

Tissue Antigens 2002 Apr;59(4):338-40
Grams SE, Moonsamy PV, Mano C, Oksenberg JR, Begovich AB.
Children's Hospital Oakland Research Institute, Oakland, California, USA, Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA, Department of Neurology, University of California, San Francisco, California, USA.

HLA-B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA-B*4422 and HLA-B*4704).

Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion-like events play an important role in generating HLA allelic diversity.

The identification of these new alleles brings the total number of HLA-B alleles to 465.