More MS news articles for August 2002

Memory CD8(+) T cells undergo peripheral tolerance

Immunity 2002 Jul;17(1):73-81
Kreuwel HT, Aung S, Silao C, Sherman LA.
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers.

In addition, memory T cells are generally believed to be less susceptible to tolerance induction than naive T cells.

In this study, we show that this is not the case.

Using two different methods of tolerance induction, peptide-induced tolerance and crosstolerance, we present evidence that memory CD8(+) T cells are as susceptible to tolerance as naive cells.

These results have a direct impact on manipulating T cell responses to self-antigens in order to improve immunotherapy of cancer and autoimmune diseases.