More MS news articles for August 2002

Autoreactive CD8 T cells in organ-specific autoimmunity. Emerging targets for therapeutic intervention

Immunity 2002 Jul;17(1):1-6
Liblau RS, Wong FS, Mars LT, Santamaria P.
INSERM U563 and Immunology Laboratory, Toulouse University Hospital, France

The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized.

Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders.

As such, these T cells now become an attractive target for therapeutic intervention.