Curr Opin Immunol 2002 Oct;14(5):569
Brinkmann V, Lynch K.
Novartis Pharma AG Transplantation Research WSJ-386.101, CH-4002, Basel, Switzerland
The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity.
Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors.
Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.