More MS news articles for August 2002

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12183155&dopt=Abstract

Curr Opin Immunol 2002 Oct;14(5):569
Brinkmann V, Lynch K.
Novartis Pharma AG Transplantation Research WSJ-386.101, CH-4002, Basel, Switzerland

The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity.

Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors.

Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.