Neuropathol Appl Neurobiol 2002 Aug;28(4):292-300
Probst-Cousin S, Kowolik D, Kuchelmeister K, Kayser C, Neundorfer B, Heuss D.
Department of Neurology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany and Institute of Neuropathology, Justus-Liebig-University Giessen, Giessen, Germany.
This study describes the distribution and identity of annexin-1 positive cells in the central nervous system in patients with multiple sclerosis (MS).
Glucocorticoid-inducible, anti-inflammatory properties have been ascribed to annexin-1, a member of a family of calcium-binding proteins that are referred to collectively as annexins.
We have found annexin-1 to be spatially associated with active MS lesions and demonstrated a stage-dependent expression of annexin-1 in MS plaques.
All of the most important pathogenetically involved cells of MS lesions showed a strong annexin-1 reactivity.
Both correlation analysis and double staining procedures suggested annexin-1 expression in macrophages and perivascular lymphocytes, where a cytoplasmic reactivity was displayed, whereas in activated, gemistocytic astrocytes it was also concentrated close to the plasma membrane.
Although the exact roles of annexin-1 in this setting are still to be determined, a possible contribution to anti-inflammatory processes might be suggested.